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Adme Enabling Technologies In Drug Design And Development

ADME Enabling Technologies in Drug Design and Development PDF

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Author: Donglu Zhang
Publisher: John Wiley & Sons
ISBN: 1118180763
Size: 13.87 MB
Format: PDF, Docs
Category : Science
Languages : en
Pages : 800
View: 4492

Book Description: A comprehensive guide to cutting-edge tools in ADME research The last decade has seen tremendous progress in the developmentof analytical techniques such as mass spectrometry and molecularbiology tools, resulting in important advances in drug discovery,particularly in the area of absorption, distribution, metabolism,and excretion (ADME). ADME-Enabling Technologies in Drug Design and Developmentfocuses on the current state of the art in the field, presenting acomprehensive review of the latest tools for generating ADME datain drug discovery. It examines the broadest possible range ofavailable technologies, giving readers the information they need tochoose the right tool for a given application, a key requisite forobtaining favorable results in a timely fashion for regulatoryfilings. With over thirty contributed chapters by an internationalteam of experts, the book provides: A thorough examination of current tools, covering bothelectronic/mechanical technologies and biologically based ones Coverage of applications for each technology, including keyparameters, optimal conditions for intended results, protocols, andcase studies Detailed discussion of emerging tools and techniques, from stemcells and genetically modified animal models to imagingtechnologies Numerous figures and diagrams throughout the text Scientists and researchers in drug metabolism, pharmacology,medicinal chemistry, pharmaceutics, toxicology, and bioanalyticalscience will find ADME-Enabling Technologies in Drug Design andDevelopment an invaluable guide to the entire drug developmentprocess, from discovery to regulatory issues.


Identification And Quantification Of Drugs Metabolites Drug Metabolizing Enzymes And Transporters

Identification and Quantification of Drugs  Metabolites  Drug Metabolizing Enzymes  and Transporters PDF

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Author: Shuguang Ma
Publisher: Elsevier
ISBN: 0128200197
Size: 14.74 MB
Format: PDF, Kindle
Category : Science
Languages : en
Pages : 708
View: 3193

Book Description: Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade’s numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism. Four sections in the book with 24 chapters give readers an overview of state-of-the-art techniques for identifying and quantifying drugs, metabolites and biomarkers, including a chapter on new approaches for quantification of enzymes and transporters in different tissues Focuses on the role of drug metabolism enzymes, transporters in disposition and drug-drug interactions, as well as strategies for evaluating drug metabolism and safety using advanced liver and kidney models. Discussions on immunogenicity risks of biologics and their evaluation methods have been included Includes several chapters on advanced translational sciences to predict human dosage, pharmacokinetics and efficacy for small molecules and biotherapeutics All chapters are written by experts with a wide range of practical experience from the industry and academia


Pharmaceutical Biocatalysis

Pharmaceutical Biocatalysis PDF

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Author: Peter Grunwald
Publisher: CRC Press
ISBN: 1000067408
Size: 27.13 MB
Format: PDF, Kindle
Category : Medical
Languages : en
Pages : 424
View: 2436

Book Description: Volume 7 of the Jenny Stanford Series on Biocatalysis deals with several different aspects of pharmaceuticals, which include not only various applications of drugs and their metabolism but also natural resources for active pharmaceutical ingredients as well as the removal of pharmaceutical pollution. In detail, novel approaches for developing microbial fermentation processes to produce vitamin B6 using microorganisms are described together with novel routes for vitamin B6 biosynthesis. The other topics discussed are new approaches for producing the successful anticancer drug Taxol from naturally occurring precursors, molecular farming through plant engineering as a cost-effective means to produce therapeutic and prophylactic proteins, and successful screening of potent microorganisms producing L-asparaginase for various chemotherapeutic applications. Furthermore, microbial biotransformations in the production and degradation of fluorinated pharmaceuticals are described. The other chapters inform the reader about the biotransformation of xenobiotics/drugs in living systems, the degradation of pharmaceuticals by white-rot fungi and their ligninolytic enzymes, and the removal of pharmaceutical pollution from municipal sewage using laccase.


Handbook Of Drug Metabolism Third Edition

Handbook of Drug Metabolism  Third Edition PDF

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Author: Paul G. Pearson
Publisher: CRC Press
ISBN: 1482262045
Size: 58.10 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 750
View: 1395

Book Description: This book continues to be the definitive reference on drug metabolism with an emphasis on new scientific and regulatory developments. It has been updated based on developments that have occurred in the last 5 years, with new chapters on large molecules disposition, stereo-selectivity in drug metabolism, drug transporters and metabolic activation of drugs. Some chapters have been prepared by new authors who have emerged as subject area experts in the decade that has passed since publication of the first edition.


Science

Science PDF

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Author:
Publisher:
ISBN:
Size: 18.46 MB
Format: PDF, Kindle
Category : Science
Languages : en
Pages :
View: 6831

Book Description:


Comprehensive Medicinal Chemistry Ii

Comprehensive medicinal chemistry II PDF

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Author: John B. Taylor
Publisher: Elsevier Science Ltd
ISBN: 9780080445137
Size: 78.75 MB
Format: PDF, Docs
Category : Computers
Languages : en
Pages : 7200
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Book Description: The first edition of Comprehensive Medicinal Chemistry was published in 1990 and very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes over the past decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and more. The content comprises the most up-to-date, authoritative and comprehensive reference text on contemporary medicinal chemistry and drug research, covering major therapeutic classes and targets, research strategy and organisation, high-throughput technologies, computer-assisted design, ADME and selected case histories. It is this coverage of the strategy, technologies, principles and applications of medicinal chemistry in a single work that will make Comprehensive Medicinal Chemistry II a unique work of reference and a single point of entry to the literature for pharmaceutical and biotechnology scientists of all disciplines and for many industry executives as well.Comprehensive Medicinal Chemistry II will be available online in 2007 via the proven platform ScienceDirect providing the user with enhanced features such as cross-referencing and dynamic linking. * Comprehensively reviews - for the first time in one single work - the strategies, technologies, principles and applications of modern medicinal chemistry * Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets * Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs


Research Development

Research   Development PDF

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Author:
Publisher:
ISBN:
Size: 66.72 MB
Format: PDF
Category : Research, Industrial
Languages : en
Pages :
View: 7025

Book Description:


New Scientist

New Scientist PDF

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ISBN:
Size: 10.59 MB
Format: PDF, Kindle
Category : Science
Languages : en
Pages :
View: 1084

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Genetic Engineering News

Genetic Engineering News PDF

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Author:
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ISBN:
Size: 39.64 MB
Format: PDF, ePub
Category : Genetic engineering
Languages : en
Pages :
View: 4743

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The Economist

The Economist PDF

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Author:
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ISBN:
Size: 63.12 MB
Format: PDF, Mobi
Category : Commerce
Languages : en
Pages :
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Book Description: