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Antiangiogenic Cancer Therapy

Antiangiogenic Cancer Therapy PDF

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Author: Darren W. Davis
Publisher: CRC Press
ISBN: 9781420004298
Size: 69.18 MB
Format: PDF, ePub, Docs
Category : Science
Languages : en
Pages : 864
View: 5083

Book Description: Top Investigators Explore the Complexities of Angiogenesis Cancer Research The targeting of tumor angiogenesis has evolved into one of the most widely pursued therapeutic strategies. However, as of yet, no antiangiogenic agent used as a monotherapy has demonstrated a survival benefit in a randomized Phase III trial. The combination of bevacizumab, the first FDA approved angiogenesis inhibitor, with cytotoxic regimens has led to survival benefits in cancer patients. This has raised important questions about the complexities inherent in the clinical application of angiogenesis inhibitors. Compiles the results of four decades of progress Integrating fundamental concepts with therapeutic strategies, Anti-Angiogenic Cancer Therapy promotes the idea that an understanding of the molecular and cellular regulation of angiogenesis leads to optimal therapeutic strategies and positive clinical results. It brings together contributions from leading researchers to provide the most authoritative and encyclopedic volume available on this subject. Examines the role of angiogenesis in cancer, including strategies to prolong the nonangiogenic dormant state of human tumors, molecular mechanisms and cellular regulation of angiogenesis in solid tumors and hematologic malignancies, and the regulation of angiogenesis by the tumor microenvironment. Covers specific molecular targets for inhibiting angiogenesis in cancer therapy. Discusses clinical trial design and translational research approaches essential for identifying and developing effective angiogenesis inhibitors. Outlines current understanding of the molecular biology of each cancer type followed by discussions that examine strategies for targeting angiogenesis in specific cancers. This volume celebrates progress made in four decades, and more importantly, it provides a clear indication of the complex biology that needs further investigation to realize the possibilities envisioned for this beneficial therapeutic modality.


Antiangiogenic Agents In Cancer Therapy

Antiangiogenic Agents in Cancer Therapy PDF

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Author: Beverly A. Teicher
Publisher: Springer Science & Business Media
ISBN: 9781597451840
Size: 21.42 MB
Format: PDF, ePub
Category : Medical
Languages : en
Pages : 559
View: 439

Book Description: This volume represents a compendium of scientific findings and approaches to the study of angiogenesis in cancer. The second edition of Antiangiogenic Agents in Cancer Therapy is intended to give a current perspective on the state-of-the-art of angiogenensis and therapy directed at this process. Antiangiogenesis is a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge.


Angiogenesis Therapeutic Targets In Cancer

Angiogenesis   Therapeutic Targets in Cancer PDF

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Author: Malay Chatterjee
Publisher: Bentham Science Publishers
ISBN: 1608050076
Size: 63.69 MB
Format: PDF
Category : Medical
Languages : en
Pages : 225
View: 5626

Book Description: Angiogenesis plays rate limiting roles in tumor growth and invasion. Angiogenesis inhibition has been proposed as a general strategy to fight against cancers. This book covers different therapeutic targets for angiogenesis interventions with emphasis on c


Sensitization Of Cancer Cells For Chemo Immuno Radio Therapy

Sensitization of Cancer Cells for Chemo Immuno Radio therapy PDF

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Author: Benjamin Bonavida
Publisher: Springer Science & Business Media
ISBN: 9781597454742
Size: 47.59 MB
Format: PDF, Mobi
Category : Medical
Languages : en
Pages : 420
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Book Description: This book reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. It also introduces several current approaches developed by established investigators that are aimed at overcoming resistance. This is the first volume to compile studies on tumor cell sensitization. It will prove useful for students, scientists, clinicians and pharmaceutical companies.


Cancer Treatment

Cancer Treatment PDF

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Author: Letícia Rangel
Publisher: BoD – Books on Demand
ISBN: 9535110985
Size: 24.13 MB
Format: PDF
Category : Medical
Languages : en
Pages : 630
View: 4923

Book Description: Cancer Treatment: Conventional and Innovative Approaches is an attempt to integrate into a book volume the various aspects of cancer treatment, compiling comprehensive reviews written by an international team of experts in the field. The volume is presented in six sections: i) Section 1: Cancer treatment: Conventional and innovative pharmacological approaches; ii) Section 2: Combinatorial strategies to fight cancer: Surgery, radiotherapy, backytherapy, chemotherapy, and hyperthermia; iii) Section 3: The immunotherapy of cancer; iv) Section 4: Multidisciplinarity in cancer therapy: nutrition and beyond; v) Section 5: Supportive care for cancer patients; vi) Section 6: Perspectives in cancer biology and modeling. Ultimately, we hope this book can enlighten important issues involved in the management of cancer, summarizing the state-of-the-art knowledge regarding the disease control and treatment; thus, providing means to improve the overall care of patients that daily battle against this potentially lethal condition.


Angiogenesis Inhibition

Angiogenesis Inhibition PDF

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Author: Rüdiger Liersch
Publisher: Springer Science & Business Media
ISBN: 9783540782810
Size: 31.87 MB
Format: PDF
Category : Medical
Languages : en
Pages : 231
View: 4762

Book Description: Angiogenesis is attracting increased scientific and clinical interest. The identification of novel mediators and targeting molecules has led to significant progress in our understanding of tumor angiogenesis and tumor vessel targeting. Important advances in cancer treatment have already emerged, and in the future, blood vessel targeting will play a significant role within individualized therapeutic strategies. This volume provides a general overview of the latest developments in angiogenesis inhibition in cancer. All aspects from the bench to the bedside are considered, with detailed attention both to basic research and to its translation into clinical practice. Individual chapters are devoted to the roles of angiopoietins, HIF-1a, chemokines, PDGF and VEGF, and vascular integrins. The latest results of clinical trials are presented, and various advanced targeting strategies are discussed. This book will be invaluable to all who wish to learn of the most recent advances in this exciting field.


Vascular Endothelial Growth Factor Receptors Advances In Research And Application 2011 Edition

Vascular Endothelial Growth Factor Receptors  Advances in Research and Application  2011 Edition PDF

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Author:
Publisher: ScholarlyEditions
ISBN: 1464955646
Size: 11.89 MB
Format: PDF, Docs
Category : Science
Languages : en
Pages : 22
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Book Description: Vascular Endothelial Growth Factor Receptors: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Receptor Protein-Tyrosine Kinases in a compact format. The editors have built Vascular Endothelial Growth Factor Receptors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Receptor Protein-Tyrosine Kinases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Vascular Endothelial Growth Factor Receptors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.


Chemoradiation In Cancer Therapy

Chemoradiation in Cancer Therapy PDF

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Author: Hak Choy
Publisher: Springer Science & Business Media
ISBN: 1592593259
Size: 14.74 MB
Format: PDF, Mobi
Category : Medical
Languages : en
Pages : 420
View: 2627

Book Description: Internationally recognized experts in cancer biology and clinical research review the present status of the multimodality approach to the management of solid tumors and speculate on possible future strategies for chemoradiation therapy. The authors detail applications of combined modality therapy in lung, esophageal, breast, gastric, pancreatic, colon, and rectal cancers. They also show how radiation interacts with such chemotherapeutic agents as the platinum complexes, taxanes, and gemcitabine in the treatment of malignant gliomas, and head and neck cancer. A review of how to integrate new specific molecular targeted agents into multimodality therapy in the future.


Neurologic Complications Of Cancer Therapy

Neurologic Complications of Cancer Therapy PDF

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Author: Eudocia Quant Lee, MD, MPH
Publisher: Demos Medical Publishing
ISBN: 1617050199
Size: 39.44 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 200
View: 2009

Book Description: Neurologic side effects of cancer therapy can inhibit treatment, can be dose-limiting and can diminish quality-of-life. Neurotoxicity related to cancer therapy is a common problem in oncology practice and in clinical neurology. Recognition of neurologic complications of anticancer therapy is necessary due to potential confusion with metastatic disease, paraneoplastic syndromes or comorbid neurologic disorders that do not require reduction or discontinuation of therapy. Neurologic Complications of Cancer Therapy provides comprehensive coverage of the recognition and management of neurologic symptoms related to cancer therapy. The book includes sections on systemic therapy discussed by both agent and adverse event. The section on adverse events is particularly valuable to clinicians, allowing them to consult by symptom in cases where multiple agents have been administered and the source of the complication is uncertain. The systemic therapy section includes coverage of immunologic agents, biologics, and targeted therapies. The book also features sections on the complications of radiation therapy, complications of surgery and high-dose chemotherapy, and stem cell transplantation. Neurologic Complications of Cancer Therapy Features: A widely recognized team of editors Systemic therapy covered by therapeutic agent and by adverse event, enabling a "problem-oriented" approach for the clinician Coverage of newer modalities including immunologic agents, biologics, and targeted therapies Complete sections on complications of radiation therapy, surgery, high-dose chemotherapy, and stem-call transplantion


Oncogene Directed Therapies

Oncogene Directed Therapies PDF

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Author: Janusz W. Rak
Publisher: Springer Science & Business Media
ISBN: 1592593135
Size: 54.44 MB
Format: PDF
Category : Medical
Languages : en
Pages : 487
View: 6658

Book Description: Prominent investigators and clinicians summarize in a balanced blend of fundamental science, basic research, experimental therapeutics, and early clinical experiences, what is known about oncogenes and oncogenesis, and describe how that knowledge can be used to treat the cancer. The contributors explain how, why, and under what conditions certain proteins acquire the ability to transform eukaryotic cells, and detail the crucial biological consequences of this oncogenic transformation, particularly for cellular mitogenesis, survival, differentiation, migration, proteolysis, or angiogenic competence. Their articles thoroughly explicate the premises, principles, techniques, and approaches to oncogene targeting in various types of human cancer by using signal transduction inhibitors, immunological targeting methods, and antisense gene therapy.