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Human Toxicology Of Chemical Mixtures

Human Toxicology of Chemical Mixtures PDF

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Author: Harold Zeliger
Publisher: William Andrew
ISBN: 0080947689
Size: 48.95 MB
Format: PDF, Mobi
Category : Technology & Engineering
Languages : en
Pages : 400
View: 6900

Book Description: This book considers how exposure to toxic mixtures affects the different physiological systems and organs, including the respiratory, cardiovascular, immunological, musculoskeletal, nervous and reproductive systems, as well as the various organs, including the kidneys, liver and skin. The author evaluates various sources of exposure, including air, water, and soil pollution; in utero exposure; chemicals contained in foods, cosmetics, and domestic cleaning products; adhesives and paints; industrial chemicals; pesticides; electromagnetic radiation; and chemicals ingested or inhaled during the use of alcohol, tobacco and narcotics. Human Toxicology of Chemical Mixtures also examines the interplay between exposure to these mixtures and the prevalence of various diseases and conditions, including autism, attention deficit hyperactivity disorder (ADHD), developmental neurotoxicology, multiple chemical sensitivity (MSC), chronic fatigue syndrome (CFS), fibromyalgia (FM), Gulf war syndrome, cancer and cancer clusters. The author also discusses how exposure to these mixtures yields the above diseases and conditions in different populations: fetuses, infants, pre-adolescent children, adolescents and adults. Finally, the book addresses the profound policy implications for formulation, labeling and use of chemical products, and it proposes more stringent exposure limits and warning requirements in light of the newly recognized toxic effects that are directly attributable to the mixture of toxic lipophilic and hydrophilic chemicals. * Addresses chemical mixtures, while most literature only deals with single chemicals exposure. * Explains why certain toxicological effects are observed. * Discusses diagnosis and treatment of injuries resulting from exposure. * Explores consequences of effects on product formulation, use, handling and required warnings. * Provides guidelines for safer development of personal care, cosmetic, industrial and consumer use products.


Toxicology Of Chemical Mixtures

Toxicology of Chemical Mixtures PDF

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Author: Raymond S.H. Yang
Publisher: Elsevier
ISBN: 1483289400
Size: 61.46 MB
Format: PDF, ePub
Category : Medical
Languages : en
Pages : 720
View: 955

Book Description: Although toxicologic studies in the laboratory often focus on a single chemical, in the larger world, mixtures of chemicals are routinely encountered. Toxicology of Chemical Mixtures examines the mechanisms of interactions and health effects stemming from chemical mixtures in the environment. Toxicologists, pharmacologists, environmental scientists, and professionals involved in environmental clean-ups will benefit from its content. Emphasis is on low-level, long-term exposure. Key Features * Some of the issues addressed include: * Target organ toxicities in response to chemical mixture exposures * Risk assessment and experimental approaches * Case studies and special pollution problems * Special pollution problems


Mixture Toxicity

Mixture Toxicity PDF

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Author: Cornelis A. M. van Gestel
Publisher: CRC Press
ISBN: 9781439830093
Size: 73.26 MB
Format: PDF, Kindle
Category : Medical
Languages : en
Pages : 320
View: 4686

Book Description: In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology and classic human toxicology, Mixture Toxicity: Linking Approaches from Ecological and Human Toxicology incorporates extensive reviews of exposure to toxicants, toxicokinetics and toxicodynamics, toxicity of mixtures, and risk assessment. The book examines developments in both fields, compares and contrasts their current state of the art, and identifies where one field can learn from the other. Each chapter provides an essential overview of the state of the art in both human and ecotoxicological mixture risk assessment, focusing on the work published in the last fifteen years. The coverage progresses from exposure to risk assessment, at each step identifying the special complications typically raised by mixtures. Based on in-depth discussions among specialists representing different disciplines and approaches, the chapters each address: Exposure — how to quantify the amounts of chemicals that may enter the living organism Kinetics, dynamics, and metabolism — how the chemicals enter an organism, travel within the organism, how they are metabolized and reach the target site, and explain development of toxicity with time Toxicity — what are the chemicals’ detrimental effects on the organism Test design and complex mixture characterization — how chemicals interact, how to measure effects of mixtures, and how to identify responsible chemicals Risk assessment — how to assess for risks in humans and the environment An unusual combination of different points of view on exposure to and risk assessment of chemical mixtures, this book summarizes current knowledge on combined effects of toxicant mixtures, information that is generally only available in a very fragmented form as individual journal papers. It identifies possible crosslinks and includes recommendations for mutual developments that can improve the state of knowledge on mixture toxicity and ultimately lead to better and more integrated risk assessment.


Principles And Practice Of Mixtures Toxicology

Principles and Practice of Mixtures Toxicology PDF

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Author: Moiz Mumtaz
Publisher: John Wiley & Sons
ISBN: 3527632115
Size: 21.56 MB
Format: PDF, Mobi
Category : Science
Languages : en
Pages : 662
View: 4663

Book Description: This first comprehensive treatment of the subject for more than a decade includes the latest research on nanoparticle toxicology. The practical handbook addresses all areas where toxic mixtures are encountered, from environmental via occupational to medical settings, giving special consideration to air and water, and to the specific requirements for study design in mixture toxicology. While no extensive prior knowledge or toxicological experience is required, the practice-oriented case studies and examples in the second part make this the ideal companion for the professional toxicologist in industry or healthcare institutions with little time for academic study.


Comprehensive Toxicology

Comprehensive toxicology PDF

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Author: I. Glenn Sipes
Publisher:
ISBN:
Size: 38.61 MB
Format: PDF, Mobi
Category : Medical
Languages : en
Pages : 498
View: 1911

Book Description: